There is no such thing as the best biological agent for ankylosing spondylitis. Patients with ankylosing spondylitis need to take medication, surgical treatment, physical therapy and functional exercises to improve their symptoms. At present, there is no clinical treatment of ankylosing spondylitis the best biological agents, for the emergence of mandatory spondylitis patients, you can use non-steroidal anti-inflammatory drugs under the guidance of the doctor, such as diclofenac sodium, and so on. Some patients can also use anti-tumor necrosis factor alpha antagonists such as infliximab and adalimumab as prescribed by the doctor. For patients with severe ankylosing spondylitis, total hip replacement and corrective spinal surgery can be taken under the guidance of doctors. In addition, patients also need to take functional exercise methods, such as under the guidance of a professional doctor, hands on the ground, two arms straight, knees kneeling, and then place the head in the middle of the two arms, try to arch the back upward, and then raise the head so that the back concave. It is recommended that patients with ankylosing spondylitis consult a rheumatologist in a timely manner and take appropriate measures to treat the disease as prescribed by the doctor.