The best treatment plan must refer to the patient’s status, such as early, middle or late stage. Specific details are as follows: 1. The most early lesion is very early, and even mucosal resection can be done through gastrointestinal endoscopy, but the tumor continues to invade to the muscle layer of the stomach wall, then open surgery or laparoscopic surgery is needed; 2. After surgery, according to the pathology report, combined with some factors, such as the degree of tissue differentiation and lymph node metastasis, whether adjuvant chemotherapy or radiotherapy is needed; 3. distant metastasis or local invasion, such as invasion to the pancreas or hepatoportal area, which cannot be done by surgery, and then systemic treatment is needed. There are many systemic treatment methods, including chemotherapy, targeted therapy and immunotherapy, all of which can be chosen. Nowadays, we still advocate to have the specimen of gastric cancer tested, such as HER-2 test, to see if there is any chance of targeted therapy. In addition, PD-L1, EBV virus, and even microsatellite stability testing can guide whether there are opportunities for targeted immunotherapy, which are all new treatment options.