Inflammation of the penile tunica vaginalis may be related to bacterial infection, fungal infection, trichomonas infection, and the main treatment includes perineal cleansing, medication, etc., such as erythromycin ointment, clotrimazole ointment, metronidazole and so on. 1. Bacterial infection: when there is a bacterial infection in the penile tunica, it can be treated with topical erythromycin ointment, mupirocin ointment and other medications, and when it is serious, it is also necessary to cooperate with oral medication, such as cefixime. 2. Fungal infections: for fungal infections caused by inflammation of the penile epidermis, after diagnosis, the first use of sodium bicarbonate solution rinse, and then topical clotrimazole ointment, and in serious cases need oral itraconazole. 3. Trichomonas infection: may be related to unclean sex, can lead to trichomonas infection of the penile epidermis, after diagnosis, can be applied to a low concentration of potassium permanganate solution, and then the use of metronidazole and other drugs. To summarize, if there is an inflammation of the penile epidermis, you should consult a doctor in time. In the use of medication must listen to the doctor’s guidance, safe and reasonable use of medication, not unauthorized use of medication.