If lymph nodes are found during lung cancer surgery, surgery, chemotherapy, radiotherapy and targeted therapy should be adopted as appropriate according to the location of lymph nodes and whether distant metastasis occurs. If the lymph nodes are located in the ipsilateral bronchus or around the ipsilateral hilum, and no distant metastasis has occurred, then surgery can be preferred; if the lymph nodes are located in the ipsilateral mediastinum and subglottic region, chemotherapy is recommended, and after chemotherapy, surgery can be carried out according to the results of the review, if necessary. In addition, if the lymph nodes are located in the contralateral mediastinum or contralateral hilum, or if the lymph nodes are present on both the ipsilateral and contralateral clavicle. Surgery is not recommended in this case, and most of them are treated with chemotherapy or radiotherapy. In case of adenocarcinoma, targeted therapy can be considered according to the gene mutation. When lymph nodes are found during lung cancer surgery, appropriate measures should be taken by doctors according to patients’ specific conditions, and family members and patients should actively cooperate with doctors, which is conducive to controlling patients’ conditions.