Both multiple and solitary breast nodules have a chance of becoming cancerous, and it is not possible to determine which is more likely to become cancerous based on whether a breast nodule is multiple or solitary. Multiple and solitary breast nodules are both space-occupying lesions that occur in the breast. Nodules are only a morphologic description, and the gold standard for determining whether a breast nodule is benign or malignant is pathologic examination. Multiple nodules are more often benign, presenting as multiple hypodense or homogeneous lesions within the gland, usually with a smooth surface, i.e., with an intact peritoneum. However, if the multiple nodules increase in size rapidly, they may be more likely to become cancerous. While single nodules can be benign or malignant, if they are benign, they are usually not cancerous, but there is still a possibility that they may become cancerous. If it is a malignant single breast nodule itself, the chance of cancer will be higher. It is recommended that breast nodules, whether multiple or single, should go to regular hospitals in time and be actively treated under the guidance of professional doctors.