Redness, swelling and lumps at the vaccine site can be caused by improper injection practices, secondary bacterial infections and allergic reactions. Usually, general treatment and medication can be used. 1. Improper injection: If the injection is too shallow, the dose is too large, or the vaccine is not shaken well, redness, swelling and hard lumps at the vaccine site may occur. Hot compresses can be used to alleviate the symptoms by dilating blood vessels, improving local blood circulation and promoting local metabolism. 2. Secondary bacterial infection: premature bathing or strenuous exercise, the vaccine in contact with bath water or sweat, causing bacterial infection, redness, swelling and hard lumps of symptoms. Cefixime can be used for treatment, the antibacterial mechanism of cefixime is mainly through the inhibition of bacterial cell wall synthesis, so as to play an antibacterial effect, so as to alleviate the symptoms of redness, swelling and hard lumps at the vaccine. 3. Allergic reaction: It may be due to allergy, may have an allergic reaction to the vaccine, so the symptoms of redness, swelling and hard lumps at the vaccine. Chlorpheniramine maleate can be used for treatment, so it can antagonize histamine-induced capillary dilatation, thus reducing capillary permeability, with anti-allergic effect, thus alleviating the redness, swelling and lumps at the vaccine. If the patient has redness, swelling and hard lumps at the vaccine, it is recommended to go to the hospital in time to find out the cause and then targeted treatment.