Adenocarcinoma that develops into advanced stage is usually difficult to be cured, and the 5-year survival rate is about 5%. Adenocarcinoma in advanced stage is often combined with lymph node metastasis or distant metastasis in liver, lungs, adrenal glands, brain tissues, bones and other parts of the body. At this time, the patient’s lymph vessels or blood vessels may be filled with a large number of adenocarcinoma cells, and these adenocarcinoma cells may flow to other organs, tissues or lymph nodes of the body along with the blood or lymphatic fluid to form new metastatic cancers. These advanced adenocarcinoma patients are not able to undergo radical surgical resection and can only adopt relatively conservative internal medicine treatments, such as chemotherapy, targeted therapy and immunotherapy, to control the progression of the disease and prolong their lives. The purpose of treatment for advanced patients is to delay disease progression and improve patients’ quality of life, and it is recommended that patients should be actively treated in order to prolong the survival period.