Itchy skin caused by liver cancer may be located in several parts of the body, especially in the trunk or the end of the limbs. It is mainly due to the damage of liver function and elevation of bilirubin in the middle and late stages of liver cancer. In the early stage of hepatocellular carcinoma, itchy skin usually does not appear; as the disease progresses to the middle or late stage, due to the damage of liver function and obstruction of bile drainage, resulting in jaundice, bilirubin in the body is elevated. Bilirubin can irritate the nerve endings of the skin, resulting in itching. The scope of skin itching is usually larger and may be located on the skin of the whole body, which is a more common accompanying symptom of advanced liver cancer. It is recommended that liver cancer patients with itchy skin should consult the doctor in time and take appropriate treatments according to their own conditions, so as to alleviate their discomfort and improve their quality of life.