The best time to take statins varies from statin to statin. For example, lovastatin is best taken at dinner. 1. The best time to take lovastatin and simvastatin is at dinner time. These two lipid-lowering drugs belong to the lipophilic lactone ring-type structure, half-life of 1~4 hours, the peak plasma concentration appears in 1~4 hours after serving, food can improve its bioavailability, it is best to take at dinner. 2. The best time to take pitavastatin, pravastatin and fluvastatin is before bedtime. The half-life of pitavastatin is about 4 hours, pravastatin’s half-life is 1.5~2 hours, and fluvastatin’s half-life is 0.5~1.2 hours. The three of them are both fat-soluble and water-soluble, and their oral intake is not affected by food, so the three of them are the best to be taken before bedtime. 3. Rosuvastatin and atorvastatin can be taken at any time of the day. The half-life of both is about 20 hours and absorption is not affected by food, so taking them is not limited by time or food. Although statins are all HMG-CoA reductase inhibitors, their indications, absorption rates, strength of action, and adverse effects are not the same due to structural differences; therefore, statins should be taken on the advice of a doctor and in a standardized manner.