A patient with bitterness in the mouth and bad breath suggests the presence of bile reflux or even a combination of H. pylori infection. H. pylori is a more common type of bacterial infection in lesions of the gastrointestinal tract. When H. pylori infects the digestive tract, especially the stomach, it can cause poor peristaltic function of the patient’s gastrointestinal tract and even induce gastric ulcers. Bile will enter the duodenum with the bile duct and then enter the small intestine for food digestion. If the peristaltic function of the gastrointestinal tract is seriously affected, bile will not be able to enter the duodenum effectively and may reflux into the stomach and esophagus, leading to a bitter feeling in the patient’s mouth along with bad breath. Therefore, when patients experience the above symptoms, they should be treated for the cause. Such patients should have a diet structured with vegetables and fruits to facilitate the peristalsis of the gastrointestinal tract. When patients are found to be positive for H. pylori, they can use a quadruple dose of amoxicillin, pantoprazole, gigastrin capsules, and clarithromycin to protect their stomachs from bacteria. In addition, patients can be treated with drugs that regulate the peristalsis of the gastrointestinal tract, such as morpholine and mosapride.