Cranial defects are a common disorder in neurosurgery, often occurring after surgical treatment for traumatic brain injury, cranial hemorrhage, and brain tumors. Cranial defects can cause certain harm and impact on the human body, and neurosurgery generally recommends prompt cranial repair surgery if the defect is more than three centimeters in diameter. Of course, there are times when skull defects may not exist alone, but may be combined with some brain damage. Some patients ask if hyperbaric oxygen can be used for skull defects. Hyperbaric oxygen is indeed a good treatment for craniocerebral trauma, cerebral hemorrhage, cerebral infarction and other brain injuries, which can have a better improvement and recovery effect and can promote the repair of brain nerve function. However, the rehabilitation department of some hospitals or the department where the hyperbaric oxygen is located may have other regulations, and feel that patients with cranial defects lack cranial protection and may not be suitable for hyperbaric oxygen therapy, so this is subject to the regulations of the specific department. After cranial repair, there is no problem, and if needed, hyperbaric oxygen therapy can be performed safely. Therefore, for patients with cranial defects, it is recommended to perform cranial repair surgery in a timely manner. According to the neurosurgery guidelines, it is generally recommended that it is a better time to perform cranial repair about three months after the first surgery, that is, after debridement. Of course, the choice of repair materials and the technical experience of the surgeon are very important for cranial repair surgery, and patients and their families need to consider the choice carefully. At present, our team is good at cranial bone repair related treatment, taking the lead in introducing a new type of polyether ether ketone peek as the cranial bone repair material, and the team continuously carries out technical improvement and innovation and material optimization design, and innovatively introduces the concept of aesthetic plastic surgery, so as to carry out peek cranial bone repair plastic surgery, which can achieve the overall unity of structural integrity, functional perfection and beautiful appearance, and achieve good clinical results. The clinical results are well recognized and widely praised by the patients.