I recently had a patient in the clinic ask me what masquerade syndrome is, a disease that is not common clinically and not well understood by many physicians. In fact, masquerade syndrome is a group of diseases that can cause uveitis but are non-inflammatory in nature. So what causes uveitis-like changes? Clinically, they are commonly caused by tumors. In clinical syndromes such as retinoblastoma, intraocular-central nervous system lymphoma, uveal melanoma, intraocular metastases from malignant tumors, and foraminal retinal detachment, uveitis manifests as pus accumulation in the anterior chamber, iris nodules, and vitreous clouding. Retinal or subretinal mass lesions, etc. Such patients tend to have progressive exacerbations and are unresponsive or insensitive to glucocorticoids. Ultrasound, CT, MRI, biopsy of ocular tissues, and whole-body related examinations should be performed in suspected patients clinically to confirm or exclude the diagnosis.