General knowledge of uveitis disease

  The uvea includes the iris, ciliary body, and choroid, and what is generally referred to as uveitis is inflammation of the iris, ciliary body, and/or choroid. The current international definition of uveitis refers to inflammation of the uvea, retina and blood vessels, and vitreous humor, which is a collective term for all inflammation in the eye. The key factor in the treatment of uveitis is treatment for the cause, however, because there are over 100 different manifestations of uveitis, it is actually difficult to determine the specific cause in a short period of time.  Some patients have spent thousands of dollars on laboratory tests without identifying the specific cause. This is why some patients with uveitis are diagnosed with “idiopathic uveitis”, that is, uveitis of uncertain etiology. The complexity and difficulty of the diagnosis has led to a lot of “confusion” and “difficulty” in the treatment of uveitis.  With the continuous development of medical science and technology, there have been significant advances in the treatment of uveitis. Many diseases that were thought to be uncontrollable a few years ago have been well controlled, saving many eyes that were about to go blind. Many drugs are more effective in controlling the recurrence of uveitis in some patients, but they fall short of the “effective, curative, non-toxic” goal desired by many patients.  Drugs commonly used to treat non-infectious uveitis include: glucocorticoids (e.g., prednisone, dexamethasone, etc.), atropine, epinephrine, cyclophosphamide, azelaic acid, methotrexate, azathioprine, and cyclosporine.  These drugs have various toxic side effects and may cause a variety of systemic multi-system complications and ocular complications: such as drug glaucoma, hypertension, diabetes, perforated bleeding gastrointestinal ulcer, fracture, aseptic necrosis of femoral head, hemorrhagic cystitis, platelet reduction, leukocyte reduction, aplastic anemia, secondary tumors, leukemia, infertility, pulmonary fibrosis, hepatic impairment, renal function impairment, alopecia, skin damage, psychiatric disorders, severely reduced immunity or secondary serious infections, and other unexpected and, in severe cases, life-threatening conditions.  These toxic side effects are mild for most patients, but sometimes cannot be effectively prevented for a specific patient. Therefore, patients and their families must be careful when taking treatment for uveitis. However, it is important not to believe in advertising language such as “secret recipe, no side effects, cure”.  The right approach is to build up confidence, actively treat and prevent the occurrence of toxic side effects.