The timing of surgery is very important for Parkinson’s patients For Parkinson’s disease patients, the choice of the timing of surgery is more important, “in view of the concerns about surgery, many patients choose to have surgery in the middle and late stages, which is not desirable, too early surgery or blindly delayed surgery is not wise, surgery is too late, the patient’s brain damage is also greater, the compensatory capacity of the cells I personally think that it is better to have surgery earlier than later”, Zhang Zhenxin said, “Early surgery is also beneficial to the patient’s recovery with the help of the compensatory capacity of the cells. In addition, age and disease duration are also important factors in the choice of treatment. Younger patients have more improvement in quality of life and stiffness symptoms, fewer cognitive complications and a slower deterioration of medial symptoms. The best time to consider receiving deep brain electrical stimulation (brain pacemaker) implantation is when the disease has been in progress for more than five years, especially when the efficacy of medication has significantly decreased or when severe motor fluctuations or anisocoria occur. The reason why it is recommended to advance the timing of surgery appropriately, Zhang Zhenxin told reporters that from the current clinical experience, in some hospitals with higher level, the current technology level has allowed to advance the timing of surgery appropriately, such as combining MRI, isotope examination, olfactory examination and other ways, and through the cooperation of medical and surgical departments, it can provide more accurate diagnosis for patients. Diagnostic accuracy is the key factor affecting the timing of surgery Zhang Zhenxin said the level of diagnosis is the key factor why patients are advised to undergo surgery after the disease has reached a certain time. “The accuracy of diagnosis is a key factor affecting the outcome. Patients with accurate diagnosis generally have a more satisfactory outcome after surgery, and from clinical experience, patients with unsatisfactory outcomes are mostly related to diagnosis. For example, multi-system atrophy, the disease manifestation is very similar to Parkinson’s disease, both develop from one side of the body to the other, the initial effect of taking drugs is obvious, etc. However, for patients with multi-system atrophy, the time of drug maintenance effect is relatively short (the effect of some drugs is maintained in about six months), if the doctor is not experienced, it is easy to misdiagnose as Parkinson’s disease.” DBS may have neuroprotective efficacy For the suggestion that surgery can be appropriately advanced, Zhang Zhenxin also said, “I have experienced in the clinic that DBS (deep brain stimulation) can achieve better efficacy, and some patients still have better living conditions after extraction, which may be related to the fact that DBS has neuroprotective effects, and there are patients who can gradually reduce the This may also indicate that DBS has some neuroprotective effect.”