The occasional occurrence of leg soreness the day after drinking beer may be just a manifestation of cold legs. If the clinical manifestation of leg soreness the day after drinking beer occurs frequently, the following two situations need to be excluded. One is that the patient has potential gout, after drinking alcohol in the malt through the body’s metabolism to form hyperuricemia, causing gouty arthritis, often leading to gouty arthritis manifestations of the knees, ankles and other joints of the patient’s lower limbs. For this type of patient, the blood uric acid test can assist in the diagnosis. In addition, some individuals have certain differences in their ability to metabolize alcohol. Alcohol is metabolized into acetaldehyde and acetic acid in the human body, and some people have weak metabolism, leading to the accumulation of acetic acid in the body, which makes the muscles of the lower limbs show soreness and discomfort, and the discomfort will be relieved gradually after 2-3 days.