Acute pancreatitis or acute gastrointestinal perforation may be the cause of severe pain in the epigastric region upon movement. 1. Acute pancreatitis: food entering the body will abnormally activate pancreatic enzymes to cause the pancreas to digest itself, triggering postprandial epigastric pain on movement. In addition to abdominal pain, it may also radially spread to the lower back, causing pain, accompanied by more than vomiting, nausea, decreased urine output, lower blood pressure. It usually develops in adult males after eating too much greasy food or drinking alcohol. 2. Acute gastrointestinal perforation: acute gastrointestinal perforation induced by drinking or overeating, clinically manifested as abdominal distension, abdominal pain, diarrhea, nausea and vomiting and other symptoms, resulting in severe pain in the epigastric region upon movement. It is recommended to go to the hospital as soon as possible, perform ultrasound or abdominal CT to identify the cause of the disease and make a clear diagnosis. Patients should develop good dietary and lifestyle habits to improve the symptoms of abdominal pain. If the symptoms of abdominal pain are severe, patients need to go to the hospital in time.