Blue Rubber Blister Nevus Syndrome (Bluerubberblebnerus Syndrome) is rare and is characterized by the simultaneous occurrence of spongy or capillary hemangiomas in the skin and digestive tract, with the tumors appearing as blue blister nevus-like. If rupture occurs, hemorrhage can result. The syndrome is an autosomal dominant disorder resulting from an embryonic developmental disorder of differentiation. Pathological changes in the skin or digestive tract there are 3 kinds of cases, here we look at the specific etiology of the elaboration: 1, large cavernous hemangioma replaces the normal tissue, affecting the vital organs and blocking the tubular structures such as intestines, trachea and so on. 2, the blood sac for a complex in the thin layer of skin blue rubber-like papillae. 3, irregular blue spots, sometimes punctate, encroach on the surrounding normal skin, and thus by blue-black, blue, light blue and to the normal skin color encroachment of various pigmentation changes. Histological examination for capillary or cavernous hemangioma, smooth muscle fibers between the walls of the tube, most sweat glands near the blood vessels.