We often encounter patients with liver disease in outpatient clinics who are always taking large amounts of medications that can aggravate the burden on the liver and damage its metabolism, and expect patients with liver disease to pay attention when applying them. Be sure to inform your doctor of your recent medications during your visit. 1. Sulfonamides, para-aminosalicylic acid, finasteride, iodine-containing contrast agents, neomycin, protein allogenic hormones and contraceptives, to some extent, cause disorders of bilirubin metabolism, resulting in jaundice and elevated transaminases. 2, paracetamol, schistosomiasis treatment drugs, deworming nitrothiocyanine, treatment of chronic hepatitis 6-mercaptopurine, azathioprine and glutamycin, mitomycin, self-limitomycin, contraindomycin, actinomycin and other antitumor drugs, Antoine, a large number of niacin and other lipid-lowering drugs, the treatment of skin disease aminopterin and Chinese medicine tumble pills can cause hepatocyte necrosis due to large doses and even small doses can cause metabolic reaction And the occurrence of elevated transaminases, jaundice, there are also reports of death. 3, rifampin and isoniazid are commonly used effective anti-tuberculosis drugs, but often cause allergic hepatitis and cholestasis; treatment of diabetes methanesulfonylurea (D860), very easy to cause liver damage. Phenazine can cause severe hepatic necrosis; chlorpromazine, promazine, prochlorperazine, trifluoperazine, etc. can cause cholestatic jaundice. Erythromycin propionate causes jaundice, static tetracycline causes hepatic necrosis, and jaundice due to triacetin has been reported in many cases. 4, the abuse of altered hemodynamic vasoconstrictors and antihypertensives, general anesthetics and some sedative sleeping drugs, as well as nerve blocking drugs, long-term use of blood circulation dysfunction of the liver may cause metabolic dysfunction, resulting in delayed liver function disorders. 5, in part of acute hepatitis and chronic active hepatitis, a large number of long-term application of corticosteroids, can be due to fat metabolism disorders appear obesity, immune function suppression and secondary bacterial, mycobacterial infection. 6, well-fed patients with chronic hepatitis, long-term application of large amounts of glucose liquid sedation, can cause fatty liver, resulting in long-term poor liver function. Another example is that patients with severe hepatitis with ascites or little urine, inappropriate application of strong diuretics, often easily cause a large amount of water-electrolyte loss, inducing hepatic coma.