The toothache after drinking alcohol is obvious is likely to be the tooth itself there is inflammation such as deep caries, apical periodontitis, etc., can follow the doctor’s instructions to use non-steroidal anti-inflammatory drugs for pain relief. 1. Loxoprofen sodium: mainly used for analgesic, anti-inflammatory, etc., can relieve toothache and all kinds of pain, but pay attention to allergy to the product, the application of non-steroidal anti-inflammatory drugs after the occurrence of gastrointestinal bleeding or perforation, active ulcers, severe heart failure, etc., is contraindicated, and need to pay attention to cause gastrointestinal discomfort, dizziness, headache, and other adverse reactions occur. 2. Ibuprofen extended-release capsules: can relieve mild to moderate headache, toothache, etc., but pay attention to the use of alcohol during the period of use, in addition to the contraindications mentioned above, pregnant women, lactating women, severe hepatic and renal insufficiency are also contraindicated, but also cause gastrointestinal ulcer hemorrhage, cystitis and other adverse reactions. The above drugs can only symptomatic pain relief, so it is recommended to further to the hospital, and under the guidance of the doctor for treatment, to avoid delaying the condition, the use of drugs need to comply with medical advice.