There is no such thing as a good medicine for ankylosing spondylitis. Generally, you can choose non-steroidal anti-inflammatory drugs such as celecoxib, as well as drugs for rheumatism such as methotrexate, glucocorticoid drugs such as prednisone, and biologics such as etanercept. 1. Non-steroidal anti-inflammatory drugs (NSAIDs): Commonly used drugs include celecoxib, meloxicam, indomethacin, ibuprofen, etc., which are able to improve the symptoms of pain. 2. Drugs for rheumatism: commonly used drugs include methotrexate and salazosulfapyridine. 3. Glucocorticoid drugs: prednisone, dexamethasone, betamethasone, etc., which have anti-inflammatory effects. 4. Biological agents: etanercept, adalimumab, etc., which have the effect of suppressing the immune response. Patients with ankylosing spondylitis are advised to seek medical attention in time, and medications need to be used under the guidance of a doctor, do not self-medicate.