Taking anti-inflammatory drugs may increase transaminases. There are many types of anti-inflammatory drugs, including tetracycline antibiotics such as tetracycline, sulfonamides such as isoniazid, sulfamethoxazole, some non-steroidal anti-inflammatory drugs such as ibuprofen, diclofenac sodium, etc. There are varying degrees of hepatotoxicity, and long-term use of anti-inflammatory drugs may affect the liver function, which can lead to transaminase elevation. Don’t worry too much about the elevated transaminases after taking anti-inflammatory drugs, go to the hospital for a review after stopping the anti-inflammatory drugs for 1 week, and the elevated transaminases will usually get better. If the aminotransferase index is still elevated, you need to take hepatoprotective drugs, such as Hepatol, under the guidance of your doctor. If necessary, liver ultrasound, hepatitis B half-pair test and hepatitis C antibody test should be performed. The medication should be taken under the doctor’s guidance, avoiding self-medication, which may cause adverse effects.