1. Significant cognitive impairment. 2, Significant and uncontrollable psychiatric disorders. Not absolutely contraindicated: 1.Patients who have previously undergone disfigurement surgery. 2.Patients with stably controlled hypertension and diabetes mellitus. 3.Patients with underlying diseases of pacemaker installation, anticoagulation, antiplatelet aggregation. 4, mild affective disorders, anxiety disorders and clear hallucinations or behavioral disorders caused by PD drugs. Three indications for surgical treatment of patients with Parkinson’s disease, a gold standard Three indications: DBS Indications for the treatment of Parkinson’s disease 1, tremor or tonicity that is difficult to control with medication. 2.Inability to tolerate medication. 3.Motor fluctuations/isokinetic/optimized drug regimen cannot achieve more satisfactory disease control. A gold standard: patients with good response to dopa preparations, such patients can achieve optimal surgical results with adequate doses of medication, and postoperative medication can be reduced by 1/3 to half.