Patients with hyperhomocysteinemia can be given folic acid, vitamin B12 and other drugs for symptomatic treatment, in addition to pay attention to dietary adjustments, eat more fruits, vegetables and other foods rich in folic acid, vitamin B12. Homocysteinemia is easy to combine with cardiovascular disease, need to give treatment for the corresponding cardiovascular disease. Patients with common coronary artery disease need to be given therapeutic lifestyle improvement and secondary prevention of coronary artery disease, including the application of antiplatelet drugs, β-blockers, renin-angiotensin system inhibitors, and statin lipid regulating drugs. Positive control of risk factors, appropriate exercise, maintain an optimistic, positive attitude toward life, regular follow-up in the hospital, discomfort follow-up.