Bone marrow transplant sibling matching has a higher chance of success, the match rate with biological siblings is about 25%, and the match rate for identical twins can reach 100%. Matching with a donor is required prior to a bone marrow transplant, otherwise there is a risk of rejection. The success rate of bone marrow transplantation matching is very low when looking for it in the general population, but if the patient has siblings, bone marrow matching can be performed, and this success rate is around 25%, and clinically this probability may be higher, and in the case of identical twins the matching rate is clinically 100% due to the extreme genomic similarity of this type of matching. If a patient needs a bone marrow transplant, he or she can be matched with a sibling under the advice of a doctor, and once the match is successful, the patient can undergo a bone marrow transplant at an early stage, which is necessary for the eradication of diseases such as aplastic anemia and multiple myeloma.