Lung cancer may present with persistent and significant pain in the left shoulder blade. However, left shoulder blade pain is a relatively common clinical symptom and has no absolute relationship with lung cancer. When the diseased tissue of lung cancer invades into the chest wall, it may cause obvious and persistent radiating pain in the left shoulder blade, in addition, patients with lung cancer usually have cough, hemoptysis, chest pain, wheezing and other symptoms. When there is only a single pain in the left shoulder blade, it is not enough to confirm the occurrence of lung cancer. Other conditions such as frozen shoulder, cervical spondylosis, shoulder arthritis, etc. may cause left shoulder blade pain. If left shoulder blade pain is suspected to be caused by lung cancer, it is recommended to seek medical treatment and under the guidance of doctor, other auxiliary examinations such as lung CT, X-ray chest radiographs, etc. If it is confirmed to be lung cancer, immediate treatment should be carried out to improve the prognosis of the patient and prolong the time of the patient’s life.