Patients with gastric disease can not smoke, tobacco contains nicotine and tar. After entering the digestive system, it will cause damage to the blood vessels on the gastric mucosa, leading to vasoconstriction of the gastric mucosa, and the resistance of the gastric mucosa will decrease, and the gastric mucosa of patients with gastric diseases will be congested, erosion and ulceration, and the condition will be aggravated. Nicotine can cause damage to the cells of the stomach wall, resulting in the secretion of pepsinogen is affected, when the digestive juices of the stomach are affected can not decompose and digest the food in the stomach in a timely manner, which will affect the digestive function of the stomach and lead to indigestion. Nicotine can cause relaxation of cardia and pyloric sphincter, which will stimulate bile secretion to increase, and is prone to esophageal and gastric reflux disease, and when bile secretion is too much and excretion is affected, the chances of cholecystitis will increase.