The principle of blood perfusion is to draw the patient’s blood out of the body into a container with a solid adsorber to remove the patient’s exogenous drugs, toxins and endogenous toxins and metabolites by adsorption, purify the blood, and achieve the purpose of treating diseases. For example, in the case of common clinical organophosphorus pesticide poisoning, paraquat poisoning, Valium poisoning, and poisonous rat poisoning, some small, medium, and large molecule toxins can be removed through blood perfusion; hyperbilirubinemia and some hepatic encephalopathies can also be treated by blood perfusion; inflammatory diseases, such as severe pancreatitis, sepsis, and endotoxemia can also be treated by blood perfusion; systemic lupus erythematosus, rheumatoid arthritis, idiopathic arthritis, and endotoxemia can also be treated by blood perfusion. Systemic lupus erythematosus, rheumatoid arthritis, idiopathic thrombocytopenic purpura, hemolytic uremic syndrome, allergic purpura, multiple myeloma, myasthenia gravis, Guillain-Barre syndrome, heroin intoxication, uremic syndrome, and intractable hypertension can be treated by hemoperfusion.