Large blisters on the soles of the feet may be associated with friction, burns and viral infections, etc. In general, try to keep the blister walls intact, and break the blisters under the guidance of a doctor if necessary. 1. friction: friction caused by large blisters, there is no obvious pain and redness, generally do not need to do too much treatment. For large blisters that persistently fail to subside, a needleless needle can be used to puncture and drain the fluid in the low position of the blisters under the guidance of a doctor. 2. Scalding: large blisters caused by scalding can be punctured and drained with a sterile needle under the guidance of a doctor, and anti-infective treatment, such as topical mupirocin cream, should be given after treatment. 3. viral infection: viral infection caused by large blisters, mainly to oral antiviral drug vasiclovir, topical antiviral drugs such as acyclovir cream, etc., also need to maintain the integrity of the wall of the blisters, so as to avoid inducing infection. Large blisters on the soles of the feet may also have other causes, must avoid excessive stimulation, and try to maintain the integrity of the blister wall, and timely consultation, symptomatic treatment under the guidance of the doctor.