There are certain hazards associated with long-term use of clopidogrel in the elderly. The main ones are bleeding, gastrointestinal reactions and so on. 1. Bleeding: the incidence of long-term clopidogrel bleeding accounts for about 9.3%. Especially for gastrointestinal bleeding, skin purpura, nasal bleeding, hematuria, eye congestion and even intracranial hemorrhage and so on. 2. Gastrointestinal reactions: such as abdominal pain, dyspepsia, gastritis, etc., and diarrhea. In addition, it manifests as rash in the skin, and the neurological side effects mainly manifest as headache, vertigo, dizziness and so on. Clopidogrel is an anti-platelet aggregation drug, which is mainly used for anti-atherosclerosis treatment, and can prevent and treat the formation of blood clots. It is usually applied to patients with acute coronary syndromes and after arterial stenting. People taking clopidogrel for a long period of time should have regular rechecks of routine blood tests, coagulation function, biochemistry, etc. In addition, they should pay attention to the color of stools and other bleeding tendencies, and seek medical attention in a timely manner.