Comfort extraction is one of the painless and minimally invasive oral treatment programs, which is a holistic solution to oral anxiety and oral pain. Through the introduction of conscious sedation and minimally invasive techniques, the patient’s fear and degree of trauma are minimized to achieve the best oral treatment effect, which is comfortable, standardized, minimally invasive and humanized. The purpose of using conscious sedation in dentistry is to reduce or eliminate dental anxiety in patients with dental anxiety; to prevent dental anxiety in patients without dental anxiety; and to expose the operator to a relaxed, awake, and cooperative patient. A variety of drugs can be used to implement conscious sedation, of which nitrous oxide, or laughing gas, is the first to be used with good controllability and high safety.