Laughing gas sedation and analgesia extraction technique is a method of extracting teeth using laughing gas (N2O/O2) inhalation for sedation and minimally invasive for pain control and anxiety relief, they also make the extraction treatment a step forward towards the humanization concept of painlessness. Laughing gas is a colorless, sweet-smelling inert inorganic gas with stable physicochemical properties and no irritation to the respiratory tract. It does not undergo any biological transformation or degradation in the body, and the vast majority of it is still discharged from the body along with the exhaled breath as the original drug, with only a small amount evaporated from the skin and no accumulation effect, making it one of the safest anesthesia methods for dentistry. At present, 80% of the dental institutions in the United States have dental laughing gas sedation analgesia system. Laughing gas oxygen inhalation awake sedation is the use of laughing gas oxygen gas mixture (of which the concentration of laughing gas is not higher than 70%, while the concentration of oxygen is not less than 30%), which has a rapid analgesia, reliable results, fast recovery after surgery, no stimulation of the respiratory tract, sweet, the patient is happy to accept, safe and reliable, etc., the advantages of the patient is more likely to accept. In the complex extraction surgery, the patient due to the operation time is long and difficult with psychological fear and anxiety difficult to cooperate. Laughing gas oxygen inhalation awake sedation can quickly produce analgesic effect and relieve anxiety, patients get sedation, in the whole treatment process to stay awake, relax, comfortable, to the language command response, open mouth cooperation, cooperate with the treatment, fast onset of action and rapid recovery, in the appropriate amount of drugs and the operation of the correct situation there is almost no side effects, safety, to avoid the medical origin of psychological trauma, reduce the pressure on the doctor, save time, improve efficiency. It is safe, avoids psychological trauma of medical origin, reduces doctors’ pressure, saves time and improves efficiency. In particular, it has obvious advantages in the extraction of complex wisdom teeth, which promotes the development of tooth extraction in the direction of minimally invasive, comfortable, standardized and humanized.