Uric acid and creatinine are in a reciprocal relationship, with increased uric acid leading to further damage to kidney function and further elevation of blood creatinine. Although experts hold different opinions on whether hyperuricemia directly affects kidney function, there are studies that suggest that hyperuricemia may be associated with the development of IgA nephropathy. On the contrary, if there is a problem with kidney function after creatinine is elevated, resulting in a lower excretion rate of uric acid, it will lead to an increase in uric acid in the body and cause conditions such as gout. Therefore, to keep uric acid under control, you can take uric acid-lowering drugs, such as benzbromarone and febuxostat.