Vascular blockage has a very typical clinical symptom called 5P sign, which is composed of 5 different clinical symptoms, all of which begin with the letter P, so it is called 5P sign. 1. pain: distal ischemia caused by vascular blockage will first cause nerve ischemia, resulting in neuropathic pain; 2. pallor: due to the reduction of distal blood supply, it will cause pale skin color at the ischemic site; 3. no pulse 3. No pulse: when the blood vessel is blocked, the pulsation of the blood vessel will disappear, causing the part where the pulsation of the artery should be felt, such as the radial artery, to be unable to feel the fluctuation; 4. Abnormal sensation: local abnormal sensation will occur in nerve ischemia, and the last symptom will appear at the same time; 5. Motor dysfunction: it is also a more typical symptom of nerve ischemia.