Empty nose syndrome, also known as empty nose syndrome, is mostly caused by nasal surgical injuries and manifests as nasal congestion, dry nose, and decreased sense of smell, etc. The disease usually requires comprehensive treatment, such as topical and systemic medication. Empty nose syndrome is a medical condition that is most often caused by excessive removal of the nasal turbinates, most commonly by inferior turbinectomy, resulting in secondary nasal mucosal atrophy and a series of concomitant symptoms. Postoperatively, it leads to nasal patency, but mostly due to wide nasal passages, decreased respiratory airflow pressure compared to the preoperative period, and in severe cases, there is atrophy of the sensory nerves of the nasal mucosa. Patients feel nasal obstruction, dryness in the nasal cavity, with decreased or absent sense of smell, sometimes nasal pain and headache when breathing, and some patients may also experience dyspnea, anxiety and other uncomfortable symptoms. Empty nose syndrome can be rhinoscopy and CT examination of the nose, can be observed in the absence of nasal turbinates, nasal mucosa pale, there is dry crust attachment, also feasible cotton wool test examination, etc., according to these examinations to develop a specific treatment program. Empty nose syndrome treatment method local application of compound peppermint oil antibacterial nasal spray, physiological seawater nasal spray, etc., the whole body can take vitamin E, vitamin D, etc. to increase the secretion of the glands in the nose. Surgical treatment to narrow the excessively spacious nasal cavity. For example, submucosal filling of the inferior turbinate with a straight myofascial rib cartilage piece, and reduction of the anterior nasal aperture. In conclusion, the emergence of empty nose syndrome is recommended to consult the doctor in time, and follow the doctor’s instructions to standardize the treatment.