Prednisone is a glucocorticoid hormone drug with powerful anti-inflammatory, anti-toxic, anti-immune and anti-shock effects, so it is widely used in clinical practice. In particular, almost all diffuse connective tissue diseases have indications for systemic use of hormones, such as systemic lupus erythematosus, polymyositis, dermatomyositis, various types of vasculitis, as well as mixed connective tissue diseases, rheumatic polymyalgia, and certain arthritis. In addition, some serious infections can be treated with appropriate hormones on the basis of effective application of antibiotics, such as sepsis and meningitis. For various shock diseases, such as anaphylactic shock, toxic shock, cardiogenic shock, hypovolemic shock, etc., hormone can also be applied to treat. It is also effective for almost all allergic diseases, such as contact dermatitis, various allergic dermatitis and drug allergy.