Diltiazem works as anti-angina, anti-hypertension, contraindications include allergy to the product, hypotension, sinus node dysfunction and other contraindications, patients should follow the doctor’s instructions to use the drug. Diltiazem is a non-dihydropyridine calcium channel blocker, can inhibit calcium ions into the cardiac muscle fibers and vascular smooth muscle fibers, thereby dilating the coronary arteries and peripheral blood vessels, to play the role of anti-angina and anti-hypertension, clinically used in the prophylaxis of stable angina pectoris, as well as the treatment of hypertension. It should be noted that the use of Diltiazem related preparations is prohibited for those who are allergic to any component of the drug, hypotensive, with sinus node dysfunction, severe bradycardia, left ventricular insufficiency with pulmonary stasis, pregnant women, and those with atrioventricular block of degree II or III without a pacemaker, as well as the concomitant use of Dantrolene, antiarrhythmics and Esmolol during the period of use of the drug. Some patients may experience adverse reactions such as sinus bradycardia, rash, malaise, fever, headache, palpitations, dizziness, flushing, lower extremity edema, etc., and should consult a doctor promptly if the discomfort is serious. Patients should follow the doctor’s instructions to use the relevant preparations of Diltiazem, and avoid blindly using the drug on their own, so as not to induce side effects affecting the condition.