Stroke, also known as stroke, is mainly due to atherosclerosis and thrombosis of the arteries in the brain, resulting in narrowing or even occlusion of the lumen, leading to ischemia, hypoxia, and necrosis of brain tissues in the cerebral artery-supplied area, which leads to limited or diffuse cerebral dysfunction syndrome or acute cerebrovascular clinical events. Stroke is a common and frequent disease that jeopardizes human health. Stroke is often accompanied by mental disorders, among which post-stroke depression is the most common, which is mainly manifested as low mood, loss of interest, slow thinking, fatigue, insomnia, loss of appetite and other symptoms. Post-stroke depression can aggravate patients’ neurological impairment, which seriously affects their physical and mental health. Music therapy is an emerging discipline, which is now widely used in clinical practice as a method of psychological intervention. A large number of studies have shown that the use of music therapy to intervene in the clinical treatment of post-stroke depression can achieve better efficacy. Music therapy can be divided into active and passive music therapy, active music therapy refers to the patient in the rehabilitation process by singing, playing musical instruments or activities with music; passive music therapy that is, let the patient listen to music. In clinical practice, scholars in China have combined Chinese and Western medicine to create music current therapy and five elements music therapy. The mechanism of music therapy for stroke depression 1, Chinese medicine: China’s traditional Chinese medicine five elements doctrine has an important position and role in Chinese medicine, as early as in the “Yellow Emperor’s Classic of Internal Medicine” that is documented and applied, such as the palace, the Shang, the horn, the levy, the feather belongs to the five elements, which lays a theoretical foundation for music therapy. Traditional Chinese medicine believes that an imbalance in the internal order of the human body will lead to discomfort and disease, and the regulating effect of music can make the human body reach a state of balance between the internal and external environments, thus contributing to physical and mental health. 2.1 Music therapy can improve the excitability of the cerebral motor cortex, promote the formation of serum brain-derived neurotrophic factor, and help the recovery of nerve function. 2.2 The sound of music is a kind of harmonious acoustic vibration, which can resonate with cells and tissues, causing effects similar to cell massage, regulating the degree of cellular excitation or inhibition, and affecting patients’ heart rate, whoosh, etc., thus playing a role in improving patients’ depressive mood. 2.3 Studies have shown that music therapy has a certain vasodilating effect. It can increase blood flow, promote the drop of blood pressure and improve depression and anxiety. 2.4 Music can stimulate specific parts of the brain, such as the hypothalamus and the nucleus ambiguus, so as to make patients feel pleasure, thus promoting the improvement of depressive mood. 2.5 Research shows that active music therapy can improve patients’ memory, attention, visual-motor coordination, stimulate thinking, motivate patients’ normal life behaviors, and bring patients’ original life abilities into play. The general method of music therapy 1, first of all, to create a suitable environment for music equipment, such as specialized music therapy room, to maintain the indoor environment, comfort, temperature, humidity is appropriate, air circulation, fresh. At the same time equipped with a variety of music equipment, such as headphones, portable music players, speakers, etc., while equipped with music therapy bed. 2, before the implementation of the treatment, to make the appropriate preparations. Under the guidance of clinicians, psychotherapists, rehabilitation physicians, according to the patient’s specific condition, select the content of healthy, rhythmic, melodic music composed of music prescription. For different patients to choose the appropriate music. If the patient has special requirements, the music can be changed according to the patient’s requirements. 3.Music therapy is generally 2 times/day, 30 minutes/time, 5 days/week, 4 weeks for a course of treatment. 4, patients should discuss with patients about the gain of music, share the feeling of physical and mental pleasure, and affirm their positive emotional changes in time when the music they listen to changes. At present, music therapy has received attention and recognition in various fields at home and abroad, and the use of music therapy in the treatment of post-stroke depression patients not only helps to improve the recovery of patients’ moods, but also is inexpensive and easy to implement, and does not cause harm or burden to patients and their families. In the future, with the deepening of clinical research, music therapy will benefit more patients with post-stroke depression.