Failure to vaccinate against rabies can be divided into pre-exposure and post-exposure situations. The former generally has little effect, while the latter may lead to the onset of rabies after infection with the rabies virus, which needs to be analyzed specifically. 1. Pre-exposure unvaccinated: that is, there is a risk of exposure to rabies virus related personnel (such as veterinarians, animal breeders, etc.) do not get vaccinated against rabies, such a situation will make the above people in the exposure to rabies virus before the body does not produce immunity, increase the risk of infection during exposure, but once exposed to the exposure of the opportunity to take post-exposure immunization to prevent rabies, so although there is a certain impact, but is still within the scope of controllable. 2. After exposure without vaccination: that is, by rabid dogs or other crazy animals bite or scratch the person does not vaccinate against rabies, this kind of situation will greatly increase the risk of rabies virus infection and rabies disease, and rabies once the onset of the disease and death rate of nearly 100%, will be a serious threat to the lives of people with the disease. In addition, it should be noted that pre-exposure immunization is contraindicated for people who are allergic to rabies vaccine or have fever or uncontrolled neurological disease, etc. Post-exposure immunization has no contraindications, whereas adverse reactions such as pain at the injection site, fatigue, and dizziness may occur after vaccination. In conclusion, those who meet the indications for rabies vaccination should be vaccinated in accordance with standardized immunization procedures as much as possible, especially those with a history of rabies virus exposure, and should not blindly give up vaccination to avoid serious adverse consequences.