Esophageal cancer invading into deep muscle layer indicates that the tumor has invaded into deep muscle tissues, and further examination is needed to check whether there are lymph nodes and distant metastasis, and the main treatment modes are surgery, chemotherapy and radiotherapy. Esophageal cancer is a very common malignant tumor in digestive system. Tumor invasion into deep muscle layer is the description of the depth of tumor invasion in pathological results, which indicates that the patient’s condition is no longer in the early stage, and it can be combined with other examinations to determine the clinical staging before deciding on the next step of treatment plan, and the commonly used treatment options are surgical resection, chemotherapy, radiotherapy, and so on. Typical clinical manifestations of esophageal cancer are progressive dysphagia, choking sensation, foreign body sensation, burning sensation, stagnant sensation or fullness sensation after eating, with or without retrosternal pain, acid reflux, heartburn, belching, etc. It is suggested that patients need to do a good job in dietary management after surgery, avoid hard food to prevent irritation of the esophagus and go to the hospital for rechecking regularly.