There are several pathological types of urethral carcinoma, including squamous carcinoma, metastatic cell carcinoma and adenocarcinoma, with squamous carcinoma being the most common. Urethral cancer with urethral stricture is most commonly seen in the bulb of the urethra. There is no racial difference in male urethral cancer, and the tissue type of primary male urethral cancer varies according to its site of origin, with 60% occurring in the bulbous urethra and 30% in the penile urethra. The age of onset of the disease is from 13 to 91 years old, and most of them are over 50 years old. In the early stage, there are symptoms such as bleeding from the urethra, frequent urination, urgent urination and painful urination. The enlargement of the tumor can also cause difficulty in urination. Treatment is difficult and prognosis is poor. I. Clinical manifestations Patients usually seek medical attention with symptoms of urethral obstruction, swelling, periurethral abscess, urinary extravasation, urethral fistula and urethral discharge, etc. Some patients have symptoms of pain, hematuria or hematospermia. Rectal bimanual examination can reveal whether the tumor has extended to the prostate, anus and urogenital diaphragm. According to the clinical and pathological biopsy results for clinical staging, and according to the surgical standard male urethral cancer pathology for review. 1.Urethrography can help to determine the size and location of tumor, but cannot estimate the scope of tumor. 2.Urethral cystoscopy can observe the scope of tumor and take biopsy to further confirm the diagnosis. 3.CT and MRI examination can understand whether there are pelvic and retroperitoneal lymph node metastasis, which can help to stage the tumor. Diagnosis For elderly men with no history of urethral disease or trauma, but with symptoms of urethral bleeding or obstruction, urethral stricture aggravated during treatment, periurethral abscess or urethral fistula, urethral cancer should be suspected. Urethrography, cystourethroscopy, biopsy and cytological examination of urethral secretion or urethral flushing fluid are needed. Urethral cancer should be differentiated from acromegaly, urethral stricture, periurethral abscess, tuberculosis and penile cavernous sclerosis. Biopsy should be performed if necessary. Prognosis Most domestic cases of male urethral cancer are reported to be in advanced stage and have poor prognosis. The survival rate reported abroad is related to the location and stage of tumor. Urethral cancer of the penis has a better prognosis, with a 5-year survival rate of 43%. The use of the expanded radical surgical approach described above may alter the outcome.