Intracellular mycobacterial infections are susceptible to recurrent infections under certain conditions. Mycobacterium intracellulare infection is a slow-growing, short-bodied bacterium that can be isolated from soil, water, and animal feces to appear. The pathogenesis is still uncertain, but human infections can mainly induce chronic lung infections, as well as lymphadenitis in children. Since Mycobacterium intracellulare is a type of bacteria, it has the ability to cause recurrent infections in some cases. For example, co-infection with Mycobacterium tuberculosis is relatively complicated to treat, and the infection can recur with unscientific medication and poor immunity. In addition, it can also be co-infected with HIV, which is easy to recur and makes treatment more difficult. For this reason, once diagnosed, we need joint, early and regular treatment, and we need to use antibiotics reasonably, to avoid the emergence of drug resistance to increase the difficulty of treatment. At the same time, patients need to pay attention to balanced nutrition, reasonable exercise, pay attention to rest, so as to improve immunity and cure Mycobacterium intracellulare-induced infections as soon as possible.