Sudden death after staying up all night may have no obvious precursor, or there may be symptoms such as chest tightness and palpitations, dizziness and fatigue, and loss of appetite. Staying up late may lead to disorders of the neuroendocrine system, elevated blood pressure, causing abnormal heart function, so that the incidence of cardiovascular disease increases, and then after stress, mental excitement and other stimuli induced, sudden death may occur. In addition, long-term sedentary may also form lower extremity venous embolus, with the blood circulation to block the pulmonary artery causing pulmonary embolism and sudden death. There may be no obvious precursor to sudden death. Excessive fatigue and pulmonary embolism may cause sudden death. Sudden cardiac death is usually preceded by symptoms, such as palpitations, chest pain and other discomforts, and the patient may have underlying diseases such as coronary artery disease, and such people are more prone to sudden death after a late night. Regardless of whether there are obvious symptoms, please do not stay up late for a long time, if there is obvious chest pain, dizziness and other discomforts, please go to the hospital in a timely manner for diagnosis and treatment as prescribed by the doctor.