HPV type 52 positivity can be treated with interferon, but it is not possible to convert HPV type 52 positivity to negative by using interferon. HPV is human papillomavirus, and type 52 positive is infected with high-risk human papillomavirus, whose long-term persistent infection is closely related to the development of cervical cancer in women. Interferon drugs mainly through the inhibition of viral replication in infected cells, but also has an immunomodulatory effect, can enhance the phagocytosis of macrophages, enhance the role of lymphocytes against the virus. And can directly inhibit the proliferation of tumor cells, through the host organism’s defense ability to interfere with the growth of the tumor, so clinically can be used for HPV virus infection after the relevant diseases caused by the treatment. For example, recombinant human interferon alpha-2b gel can be used for the adjuvant treatment of condyloma acuminatum, herpes zoster, herpes orofacialis, genital herpes, and female cervical lesions. The drug is contraindicated in people who are allergic to interferon preparations, sexual intercourse and sitz baths are prohibited during the use of the drug, and the drug needs to be stopped during menstruation. Adverse reactions such as mild itching, lower abdominal swelling and increased secretion may occur after use of the drug. When HPV52 is positive and interferon is needed for treatment, it is recommended to consult a doctor in time to decide on the dosage of the drug and the duration of follow-up after a comprehensive assessment of the condition.