The best treatment for cachexia is to cure the cancer, but for patients with terminal cancer, this is an impossible task. Without high nutritional food supplements or high nutritional intravenous injections, the help for cachexia is limited. The drugs currently used in clinical practice, which focus on appetite promotion and cytokine reduction, include meto clopromiclo, steroids and high-dose progesterone; among them Especially worth mentioning is high-dose luteinizing hormone, which can promote appetite, suppress excessive consumption of energy in the body, increase body weight, and improve quality of life. In addition to the treatments described above, there are many new drugs in clinical trials, the most promising of which is thalidomide, an old drug that was marketed in 1960 and was initially used as a sleeping pill and an antiemetic, it had few side effects so it was also used in the treatment of hyperemesis gravidarum, unfortunately, it did not take long before cases of limb shortage (seal limb) malformations were reported, followed by Unfortunately, it did not take long for cases of limb shortage (seal limb) malformations to be reported, followed by cases of facial, visceral, and crestal malformations, which led to the ban. However, apart from the side effects of malformed children, the drug is generally safe. In recent years, it has gained renewed attention because, on the one hand, it inhibits the secretion of cytokine and therefore has a therapeutic effect on cachexia. According to a study by Rocky Taylor University in the June 1997 issue of the Journal of Clinical Infection, thalidomide increased the body weight of 57% of patients with cachexia and AIDS, compared to 7% of the control group. In addition, Thalidomide can inhibit blood vessel neovascularization, which is an important mechanism for cancer deterioration, so it has a therapeutic effect on cancer. Current studies have shown that Thalidomide can inhibit the deterioration and metastasis of prostate, esophageal, breast and liver cancers. Thalidomide is a multi-benefit for people with cancer combined with cachexia, and it is believed that it can be used in clinical practice in the near future. The treatment and care of cancer combined with cachexia often leaves family members and physicians at their wits’ end. The current treatment is nutritional supplementation combined with medication, such as high-dose progesterone, Meto’clopramide, and steroids, to promote appetite and improve physical health, but the results are still unsatisfactory. There are currently many drugs in clinical trials, of which Thalidomide is the star of tomorrow; hopefully in the near future there will be more good drugs that will give more help to cachectic patients and improve their quality of life. Warm tip: Please combine the specific medication with the clinical and be guided by the doctor’s face-to-face consultation.