Multiple enlarged lymph nodes throughout the body are not necessarily caused by cancer. Lymph nodes are important immune organs of the human body, and enlarged lymph nodes are a common clinical sign, which can be caused by a variety of reasons. Systemic causes of lymph node enlargement include both infectious and non-infectious diseases. Infectious diseases include the following: 1, viral infections, such as infectious mononucleosis, AIDS, etc. 2, bacterial infections, such as tuberculosis, brucellosis. 3, spirochete infections, such as syphilis, leptospirosis, etc. 4, protozoa and parasitic infections, such as filariasis. Non-infectious diseases include the following:1. Connective tissue diseases, such as systemic lupus erythematosus, desiccation syndrome, nodular disease, etc.2. Hematologic diseases, such as acute leukemia, lymphoma, etc.3. The etiologic diagnosis of generalized enlarged lymph nodes must be evaluated in conjunction with accompanying symptoms, medical history, and relevant examinations. Generally, the distribution of enlarged lymph nodes and other symptoms should be used to locate the primary lesion, combined with the corresponding auxiliary examination, and if necessary, the lesion should be removed by puncture or surgery, and pathological examination should be performed to make a clear diagnosis.