Anticholinesterase drugs, also known as indirectly acting cholinesterase drugs, can be divided into easily reversible anticholinesterase drugs and irreversible anticholinesterase drugs according to their pharmacological properties. Easily reversible anticholinesterase drugs mainly include neostigmine, bromopyridium bromide, epsilon-ammonium chloride, ampicillin, toxic lentil, dimethyramine, etc. Irreversible anticholinesterase drugs are mainly organic phosphate esters, which have toxicological significance and are rarely used clinically for disease treatment. 1, new Stimmin: quaternary ammonium compounds, can directly agonize the N receptors on the motor end plate of skeletal muscle, strong excitatory effect on skeletal muscle, excitation of gastrointestinal smooth muscle second, the role of the gland, eye, cardiovascular and bronchial smooth muscle weak. It is used for the treatment of myasthenia gravis and intestinal paralysis after abdominal surgery, and also for paroxysmal supraventricular tachycardia, and to counteract the toxic reactions of overdose of competitive neuromuscular blocking drugs; 2. Bromipyridamole: slow onset of action, longer duration of action. After oral administration, it is poorly absorbed in the gastrointestinal tract and can enter the placenta, but it is not easy to enter the central nervous system, and is mainly excreted in the form of prodrug and metabolites via urine, and a small amount is excreted from breast milk. The effect disappears after 5-15 minutes, so it should not be used as a therapeutic drug. For the diagnosis of myasthenia gravis, if the subject shows a transient improvement in muscle contraction after administration of the drug, and no symptoms of contraction of the lingual muscle fibers are seen, it indicates a positive diagnosis, and atropine should be prepared for diagnostic use to prevent serious toxic reactions. This product can be used to identify patients with myasthenia gravis with neostigmine, or bromipyridamole with inadequate or excessive dosage; 4. Ambeculium chloride: less gastrointestinal absorption, the effect lasts 4-8 hours, longer lasting than neostigmine. It is mainly used in the treatment of myasthenia gravis, especially for patients who cannot tolerate neostigmine or bromipyridamole; 5. Toxic lentil base: it can be absorbed rapidly by the stomach and intestines, subcutaneous tissues and mucous membranes, and can easily cross the blood-brain barrier. To the central nervous system, small dose excitation, large dose inhibition, with pupil reduction, reduce intraocular pressure and contraction of the ciliary muscle and cause regulation of spasm and other effects, clinical use for the treatment of acute glaucoma, you can first use this product eye drops, and then change to use Mao Guo Yunxin eye drops to maintain the efficacy. Because the drug can cause the ciliary muscle contraction after dropping, and cause regulatory spasm, and can appear headache, so when dropping the eye should be compressed intraocular angle, so as to avoid absorption poisoning after the nasal cavity; 6, Demecarium bromide: is a long-acting reversible anticholinesterase drugs, used in the treatment of glaucoma, 15-60 minutes after dropping the pupil can be seen to narrow, 24 hours after the use of the effect of lowering intraocular pressure reached a peak, the effect lasts more than 9 days It is used for the treatment of aphakic glaucoma.