Swollen calves should be treated according to the different causes of the disease with anticoagulants, immunosuppressants, thyroxine tablets, human albumin, diuretics and other drugs as prescribed by the doctor. 1. Anticoagulants: lower extremity thrombosis diseases, patients can use warfarin, rivaroxaban and dabigatran under the guidance of a doctor, taking such drugs can reduce blood clots and prevent the formation of blood clots, alleviate the phenomenon of swelling of the lower extremity caused by venous thrombosis of the calves. 2. Immunosuppressive drugs: such as nephrotic syndrome, available cyclophosphamide, cyclosporine and azathioprine and other drugs. These drugs can inhibit immunity, reduce the formation of inflammatory mediators, and relieve calf swelling caused by kidney disease. These drugs can produce gastrointestinal discomfort, allergies and thrombocytopenia and other adverse reactions, need to be used in accordance with the doctor’s instructions, allergic to the components of the drug is prohibited. 3. Hypothyroidism: Oral thyroxine tablet replacement therapy can make the swelling of the lower legs improved. 4. Hypoproteinemia: Liver failure, renal failure, etc., hypoproteinemia, protein supplementation, and treatment for the cause of the disease, generally swelling of the lower legs will be significantly improved. 5. Heart failure can make the venous blood reflux caused by obstacles, then oral diuretics, such as furosemide tablets, will make the swelling of the legs significantly reduced. If the patient’s calf swelling is serious, the phenomenon of inability to move, it is recommended to go to the hospital immediately, under the guidance of the doctor symptomatic treatment.