The treatment of gastrointestinal malformations in newborns is surgical, depending on the specific site of onset. As well as the degree of malformation to develop the appropriate treatment program. Neonatal gastrointestinal malformation if the lesion site in the intestinal tract, intestinal obstruction symptoms, the need for timely surgical treatment; if the newborn appeared electrolyte disorders, the need to correct electrolyte disorders and acid-base balance imbalance, to be stabilized after following the doctor’s orders through surgical treatment, such as duodenal anastomosis. The earlier the intervention for neonatal gastrointestinal malformations, the better the result, to avoid causing serious complications in newborns, can restore the digestion and absorption of nutrients as soon as possible, to promote the normal growth and development of newborns. Neonatal gastrointestinal malformations require parents to bring their newborns to the hospital in time, and follow the doctor’s instructions to actively treat.