Pivetronium bromide and trimethoprim are both medications used to regulate gastrointestinal dysfunction and are generally not recommended to be taken at the same time. Pivetronium bromide is a calcium antagonist that prevents excessive contraction of colonic smooth muscle cells and exerts an antispasmodic effect, increasing intestinal motility. It is commonly used in clinical practice for the treatment of pain associated with intestinal dysfunction, abnormal bowel movements and gastrointestinal discomfort and pain associated with biliary dysfunction pain, etc. It is also used to prepare for barium enema. Pivetronium bromide may cause gastrointestinal discomfort, skin rash and other adverse reactions when taking, allergy to the product, esophageal, gastric and duodenal ulcers should be prohibited, pregnant women, lactating women, children should be cautious when using the drug. Trimethoprim has the effect of regulating gastrointestinal motility, antiemetic, etc. It is commonly used in clinical practice for the improvement of symptoms caused by gastrointestinal motility disorders such as loss of appetite, nausea, vomiting, belching (hiccups), abdominal distension, abdominal tinnitus, abdominal pain, diarrhea, constipation and the treatment of irritable bowel syndrome. Trimethobenzidine in taking may it will appear constipation, diarrhea, intestinal tinnitus, numbness in the mouth and other adverse reactions, for organic, occupational gastrointestinal diseases, pregnant women, lactating women, children should be used with caution. Pivacurium bromide and trimethoprim are both drugs used to regulate gastrointestinal dysfunction, and their combined use may aggravate the occurrence of adverse reactions, therefore, it is generally not recommended to take them at the same time. However, if the patient’s condition is serious, the same dose may be considered. It is recommended to consult a doctor in advance when taking Pivaclonium Bromide and Trimethoprim, and strictly follow the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.