Blistered lips are usually herpes simplex caused by type 1 herpes simplex virus infection, acyclovir ointment has an antiviral effect and is effective against herpes simplex, so topical acyclovir ointment for blistered lips is useful. In addition to topical acyclovir ointment, you can also apply topical penciclovir cream for better results. At the same time, in order to promote the drying of blisters and crusting as soon as possible, and to promote the receding of the rash, you can also take oral antiviral drugs, such as famciclovir, valacyclovir or acyclovir, and its course of treatment for about 1 week. After the herpes has healed, patients should pay attention to strengthening their immune system, avoiding late nights and direct sunlight, as UV radiation can also induce recurrence of herpes.